Bone Marrow Stromal Cells Increase Oligodendrogenesis after Stroke

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Bone marrow stromal cells increase oligodendrogenesis after stroke.

Oligodendrocytes are sensitive to ischemic damage. The Sonic hedgehog (Shh) pathway is critical in oligodendrogenesis; Gli1 is the principal effector of Shh signaling. We investigated oligodendrogenesis and Shh/Gli1 pathway activation after bone marrow stromal cell (BMSC) treatment of stroke in rats. Rats were subjected to the middle cerebral artery occlusion (MCAo). BMSCs have been shown to pr...

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Bone marrow stromal cells and their application in neural injuries

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Bone Marrow Stromal Cells

Accepted, April 23, 2003. OBJECTIVE: We investigated the effect of human bone marrow stromal cells (hMSCs) administered intravenously on functional outcome after traumatic brain injury in adult rats. METHODS: hMSCs were harvested from three human donors. A controlled cortical impact was delivered to 27 adult male rats to induce traumatic brain injury, and 24 hours after injury, hMSCs were injec...

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Bone Marrow Stromal Cells With Exercise and Thyroid Hormone Effect on Post-Stroke Injuries in Middle-aged Mice

Introduction: Based on our previous findings, the treatment of stem cells alone or in combination with thyroid hormone (T3) and mild exercise could effectively reduce the risk of stroke damage in young mice. However, it is unclear whether this treatment is effective in aged or middle-aged mice. Therefore, this study designed to assess whether combination of Bone Marrow Stromal Cells (BMSCs) wit...

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Evaluation of the Repair of Bone Defect after Bone Marrow Stromal Cell Transplantation in Rat

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ژورنال

عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism

سال: 2009

ISSN: 0271-678X,1559-7016

DOI: 10.1038/jcbfm.2009.41